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Far more frequent checking of INR and prothrombin time in individuals using such oral anticoagulants is recommneded, Specifically on the initiation and termination of androgen therapy.[ten] It can be unclear if testosterone can increase the anticoagulant response to heparin therapy or if testosterone alters the outcome of other non-coumarin oral anticoagulants in a similar fashion.
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Testosterone can enhance the anticoagulant motion of warfarin.[eighteen] Really serious bleeding has long been reported in some sufferers using this type of drug-drug conversation. Although the mechanism is unclear, testosterone might reduce procoagulant components. Reduction of warfarin dosage may be necessary if testosterone therapy is coadministered.
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[thirty][31] The antiandrogenic effects of Saw palmetto, Serenoa repens will be predicted to antagonize the steps of androgens; it would seem illogical for sufferers getting androgens to implement this herbal nutritional supplement.
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